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Accurate results in the clinical laboratory : a guide to error detection and correction / edited by Amitava Dasgupta, Jorge L. Sepulveda.

Contributor(s): Dasgupta, Amitava, 1958- | Sepulveda, Jorge L.
London ; Waltham, MA : Elsevier, ©2013Description: xiii, 368 p. : ill. ; 28 cm.ISBN: 9780124157835 (cloth); 0124157831 (cloth).Subject(s): Diagnosis, Laboratory -- Quality control | Medical laboratories -- Quality control | Clinical Laboratory Techniques -- methods | Clinical Laboratory Techniques -- standards | Diagnostic Errors -- prevention & control | Quality ControlDDC classification: 616.075/Ac29
Contents:
1. Variation, errors, and quality in the clinical laboratory / Jorge Sepulveda -- 2. Effect of age, gender, diet, exercise, and ethnicity on laboratory test results / Octavia M. Peck Palmer -- 3. Effect of patient preparation, specimen collection, anticoagulants, and preservatives on laboratory test results / Leland Baskin, Valerian Dias, Alex Chin, Amid Abdullah and Christopher Naugler -- 4. Sample processing and specimen misidentification issues / Alison Woodworth and Amy L. Pyle -- 5. Hemolysis, lipemia, and high bilirubin : effect on laboratory tests / Steven C. Kazmierczak -- 6. Immunoassay design and mechanisms of interferences / Pradip Datta -- 7. Effect of herbal remedies on clinical laboratory tests / Amitava Dasgupta -- 8. Challenges in routine clinical chemistry testing : analysis of small molecules / Jorge Sepulveda -- 9. Challenges in routine clinical chemistry analysis : proteins and enzymes / Jorge Sepulveda -- 10. Sources of inaccuracy in biochemical genetics testing / Michael J. Bennett -- 11. Challenges in endocrinology testing / Lindsay A.L. Bazydlo, Neil S. Harris and William E. Winter -- 12. Pitfalls in tumor markers testing / Alyaa Al-Ibraheemi, Amitava Dasgupta and Amer Wahed -- 13. Issues of interferences in therapeutic drug monitoring / Gwendolyn A. McMillin and Kamisha L. Johnson-Davis -- 14. Limitations of drugs of abuse testing / Amitava Dasgupta -- 15. Challenges in confirmation testing for drugs of abuse / Larry A. Broussard -- 16. Alcohol determination using automated analyzers : limitations and pitfalls / Sheila Dawling -- 17. Pre-analytical issues and interferences in transfusion medicine tests / Elena Nedelcu -- 18. Issues with immunology and serology testing / Amer Wahed and Semyon Risin -- 19. Sources of errors in hematology and coagulation testing / Andy Nguyen and Amer Wahed -- 20. Challenges in clinical microbiology testing / Laura Chandler -- 21. Sources of errors in molecular testing / Laura Chandler -- 22. Problems in pharmacogenomics testing / Dina N. Greene, Cecily Vaughn and Elaine Lyon.
Summary: Addresses interference issues in all laboratory tests, including patient epigenetics, process of specimen collection, enzymes, and biomarkers. Intended to help clinicians become proficient in identifying erroneous reports, understand the source of interferences, correct the results, and then decide what course of action to follow for proper patient management. Suitable for both clinicians and laboratory scientists, presented in the form of tables and charts for easy reference, this title addresses interference issues in all laboratory tests, including patient epigenetics, process of specimen collection, enzymes, biomarkers. It covers interferences across endocrine, oncology, hematology, and immunology. This practical, easy-to-use guide, named to Doody's Core Titles 2013, addresses interference issues in all laboratory tests, including patient epigenetics, process of specimen collection, enzymes, biomarkers. Clinicians and laboratory scientists can therefore rely on one reference which speaks to both their needs of accurate specimen analysis and optimal patient care. Erroneous hospital and pathology laboratory results can be confusing and problematic, especially in acute care situations. While some factors creating interference, can be identified in the laboratory, detecting many others is often dependent on clinical details unavailable to the laboratory scientists or pathologists. Therefore, clinicians must become proficient in identifying such erroneous reports, and working with pathologists and laboratory scientists so that they can understand the source of such interferences, correct the results, and then decide what course of action must be followed for proper patient management. Named to Doody's Core Titles 2013, a collection development tool for health sciences libraries of all sizes, by Doody Enterprises Practical information for both clinicians and laboratory scientists, presented in the form of tables and charts for easy reference Focus on range and sources of interferences rather than details of toxicologic mechanisms which are well covered in toxicology textbooks Covers interferences across endocrine, oncology, hematology, immunohistochemistry, immunology, serology, microbiology, and molecular testing
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Includes bibliographical references and index.

1. Variation, errors, and quality in the clinical laboratory / Jorge Sepulveda -- 2. Effect of age, gender, diet, exercise, and ethnicity on laboratory test results / Octavia M. Peck Palmer -- 3. Effect of patient preparation, specimen collection, anticoagulants, and preservatives on laboratory test results / Leland Baskin, Valerian Dias, Alex Chin, Amid Abdullah and Christopher Naugler -- 4. Sample processing and specimen misidentification issues / Alison Woodworth and Amy L. Pyle -- 5. Hemolysis, lipemia, and high bilirubin : effect on laboratory tests / Steven C. Kazmierczak -- 6. Immunoassay design and mechanisms of interferences / Pradip Datta -- 7. Effect of herbal remedies on clinical laboratory tests / Amitava Dasgupta -- 8. Challenges in routine clinical chemistry testing : analysis of small molecules / Jorge Sepulveda -- 9. Challenges in routine clinical chemistry analysis : proteins and enzymes / Jorge Sepulveda -- 10. Sources of inaccuracy in biochemical genetics testing / Michael J. Bennett -- 11. Challenges in endocrinology testing / Lindsay A.L. Bazydlo, Neil S. Harris and William E. Winter -- 12. Pitfalls in tumor markers testing / Alyaa Al-Ibraheemi, Amitava Dasgupta and Amer Wahed -- 13. Issues of interferences in therapeutic drug monitoring / Gwendolyn A. McMillin and Kamisha L. Johnson-Davis -- 14. Limitations of drugs of abuse testing / Amitava Dasgupta -- 15. Challenges in confirmation testing for drugs of abuse / Larry A. Broussard -- 16. Alcohol determination using automated analyzers : limitations and pitfalls / Sheila Dawling -- 17. Pre-analytical issues and interferences in transfusion medicine tests / Elena Nedelcu -- 18. Issues with immunology and serology testing / Amer Wahed and Semyon Risin -- 19. Sources of errors in hematology and coagulation testing / Andy Nguyen and Amer Wahed -- 20. Challenges in clinical microbiology testing / Laura Chandler -- 21. Sources of errors in molecular testing / Laura Chandler -- 22. Problems in pharmacogenomics testing / Dina N. Greene, Cecily Vaughn and Elaine Lyon.

Addresses interference issues in all laboratory tests, including patient epigenetics, process of specimen collection, enzymes, and biomarkers. Intended to help clinicians become proficient in identifying erroneous reports, understand the source of interferences, correct the results, and then decide what course of action to follow for proper patient management. Suitable for both clinicians and laboratory scientists, presented in the form of tables and charts for easy reference, this title addresses interference issues in all laboratory tests, including patient epigenetics, process of specimen collection, enzymes, biomarkers. It covers interferences across endocrine, oncology, hematology, and immunology. This practical, easy-to-use guide, named to Doody's Core Titles 2013, addresses interference issues in all laboratory tests, including patient epigenetics, process of specimen collection, enzymes, biomarkers. Clinicians and laboratory scientists can therefore rely on one reference which speaks to both their needs of accurate specimen analysis and optimal patient care. Erroneous hospital and pathology laboratory results can be confusing and problematic, especially in acute care situations. While some factors creating interference, can be identified in the laboratory, detecting many others is often dependent on clinical details unavailable to the laboratory scientists or pathologists. Therefore, clinicians must become proficient in identifying such erroneous reports, and working with pathologists and laboratory scientists so that they can understand the source of such interferences, correct the results, and then decide what course of action must be followed for proper patient management. Named to Doody's Core Titles 2013, a collection development tool for health sciences libraries of all sizes, by Doody Enterprises Practical information for both clinicians and laboratory scientists, presented in the form of tables and charts for easy reference Focus on range and sources of interferences rather than details of toxicologic mechanisms which are well covered in toxicology textbooks Covers interferences across endocrine, oncology, hematology, immunohistochemistry, immunology, serology, microbiology, and molecular testing

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