000			03788nam a2200337 a 4500
001			00002259
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006			m d
007			cr buu|||uu|||
008			091123s1994 si a sb 001 0 eng d
040			_aWSPC _beng _cWSPC
020			_a9789814354189 _q(ebook)
020			_z9810216548
020			_z9810216556 _q(pbk.)
020			_z9789810216542
050	0	4	_aRC271.G45 _bG46 1994
082	0	4	_a616.99406 _222
245	0	0	_aGene therapy _h[electronic resource] : _bfrom laboratory to the clinic / _cedited by Kam M. Hui.
260			_aSingapore ; _aRiver Edge, N.J. : _bWorld Scientific Pub. Co., _cc1994.
300			_a1 online resource (viii, 278 p.) : _bill.
504			_aIncludes bibliographical references and index.
505	0		_ach. 1. An introduction to gene therapy and cancer / Y.H. Tan -- ch. 2. Clinical strategies and expectations for the molecular biotherapy of cancer / H.K.B. Silver and R.J. Klasa -- ch. 3. Tumor-directed cytokine gene therapy / C.S. Chiang ... [et al.] -- ch. 4. Therapeutic applications of antisense nuclei acids / T.M.C. Tan, E.C.B. Nadala Jr. and R.C.Y. Ting -- ch. 5. Molecular targeting of cancer: retroviral vector-mediated antisense nuclei acid therapy / V. Zhang ... [et al.] -- ch. 6. DC-chol liposomes as DNA carriers for gene therapy / A. Singhal and L. Huang -- ch. 7. Accell particle bombardment for gene transfer as a useful gene therapy technique / N.S. Yang ... [et al.] -- ch. 8. DNA-coated microprojectiles for gene delivery into live animals / D.C. Tang and S.A. Johnston -- ch. 9. Expression of "foreign" class I major histocompatibility complex (MHC) molecules on experimental tumors and the induction of active specific cancer immunotherapy / K.M. Hui -- ch. 10. Gene transfer to the central nervous system mediated by herpes simplex virus vectors / J.C. Glorioso ... [et al.] -- ch. 11. Adeno-associated virus-based vectors for human gene therapy / R.J. Samulski.
520			_aWith advances in our understanding of the molecular biology of human diseases and the development of efficient gene transfer techniques, the treatment of such diseases as cancer and infectious disease using gene therapy has progressed from a distant prospect to a distinct possibility in a very short time. The development of gene transfer methods which are suitable for different forms of therapy has been a major topic of research over the past several years. A common goal of this research has been to achieve the efficient delivery of genes into cells. The successful implementation of gene transfer as a cure for diseases, however, will continue to require the translation of preclinical studies in gene therapy into effective clinical protocols. This volume outlines the latest developments in cancer treatment using various gene delivery systems, which include cytokine gene transfer, the delivery of anti-ras DNA by retroviral vector and the injection of allogeneic HLA DNA via liposomes. Several of these molecular approaches have recently been approved by the US FDA as human clinical trial protocols in order to assess their therapeutic efficiency and safety for cancer treatment. Further developments in recombinant DNA technology within this field should ultimately lead to dramatic improvements in the practice of medicine.
533			_aElectronic reproduction. _bSingapore : _cWorld Scientific Publishing Co., _d1994. _nSystem requirements: Adobe Acrobat Reader. _nMode of access: World Wide Web.
650		0	_aCancer _xGene therapy.
655		0	_aElectronic books.
700	1		_aHui, Kam M. _q(Kam Man)
710	2		_aWorld Scientific (Firm)
856	4	0	_uhttps://www.worldscientific.com/worldscibooks/10.1142/2259#t=toc _zAccess to full text is restricted to subscribers.
999			_c121323 _d121323